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In the Metformin in Gestational Diabetes (MiG) trial published in 2008, in which patients were randomized to insulin versus metformin, there was a signal that there was an increased risk for elevated BMI and childhood overweight later in life at age 7 to 9 years in one of the cohorts

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This prevents harmful freeze-thaw cycles that can destroy the peptides structure

F., Calanna, S., Davies, M., Dicker, D., Garvey, W

Osmotic laxatives such as macrogol and bulk-forming laxatives like ispaghula husk are safe for long-term use under medical supervision

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