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Following chemotherapy, macrophages secrete interleukin-18 (IL-18), which in turn upregulates L-amino acid transporter protein 2 (LAT2) expression in tumour cells
564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice
Lubos, E., Loscalzo, J
[15] Is co-administration with nitrate therapy for angina advisable
[ in vivo assessments of BBB transport, biodistribution, and long-term neurotoxicity are still required to substantiate clinical translational potential
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