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The Bottom Line: Compelling Mechanisms Demand Rigorous Human Investigation BPC-157 presents a fascinating scientific paradox: extensive preclinical evidence spanning three decades demonstrates pleiotropic effects across multiple neurotransmitter systems, with antidepressant efficacy exceeding standard drugs in animal models, anxiolytic effects without dependence liability, neuroprotection in stroke and neurodegeneration models, and reversal of schizophrenia-like cognitive deficits
doi: 10.3389/fnins.2022.1043857 27 AstrmCLindholmJ
RL received funding from the Academy of Finland (grants 292335, 294337, 319280, 31444, 319280, 329277, 331790), from Business Finland and by grants from JDRF, the Sigrid Juslius Foundation, the Jane and Aatos Erkko Foundation, the Finnish Diabetes Foundation and the Finnish Cancer Foundation
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