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Glioblastoma (GBM) accounts for the majority of gliomas (56.6%), making it the most common malignant primary brain tumor in adults with the worst prognosis (Ostrom et al., 2018)

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A composite patient narrative: what the first cycle actually looks like The first session for most patients is awkward

Subsequent benzylation of intermediate Compound 4 , followed by its deprotection, resulted in the formation of N 2 -substituted Compound 5

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