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Following diethyl ether precipitation, the pellet was dissolved in 10 ml triethylamine containing DMSO and incubated for 1 h at 25 C, to yield the corresponding macrocycle
& Beyak, M
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These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications
The patent remained remained unchallenged and unused by Eli Lilly until its expiry
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