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We've found that researchers who stack these compounds report more consistent reductions in adipose depot size compared to single-agent protocols, likely because the dual mechanism prevents the compensatory metabolic slowdown that often undermines prolonged caloric deficits

Pratley RE, Barnett A, Feinglos MM, Harman-Hoehm I, Nauck M, Ovalle F, Johnson S, Stewart M, Ye J, Rosenstock J

Expected outcome: Some metabolic support during transition, though weight regain is common regardless of supplementation after stopping GLP-1 medications

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Equinoxs GLP-1 protocol is considered a framework for people taking the drugs, one that addresses workout intensity, frequency and volume (how many reps) as well as robust habit coaching, says the clubs senior personal training manager, Stan Ward

Most experts recommend using it in the evening, as some formulations can increase photosensitivity