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Eating food triggers the release of GLP-1 which tells your brain "Hey, we're good here, you can stop eating now." Pretty cool, right

I love that question because for a lot of people, they're not eating very much at all

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Metabolites also interface with the immune system and modulate the production of cytokines that regulate inflammatory responses, and thereby influence systemic inflammation, which has been implicated in NDDs and several other conditions ( The endocrine pathway involves interactions between metabolites and their receptors, which can induce the secretion of hormones from enteroendocrine L cells and lead to indirect signaling to the brain through systemic circulation or vagal pathways

By directly stimulating GH secretion through the GHS-R1a, Ipamorelin increases endogenous GH levels without directly supplementing growth hormone