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The suggestion that reduced nuclear environment could protect oxidant sensitive proteins from oxidation [50] could be confirmed by our results: there was less glutathionilated and more oxidised proteins when the nuclear GSH was depleted by DEM (Fig
Indeed, inflammaging is associated with cell ROS over-production leading to oxidation/damage of cellular components, enhanced inflammation, and activation of cell death pathways
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Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
PubMed Central, Yildirim Simsir, Ilgin, et al